NuviQue CaHA Combo – Triple Combo Action CaHA Biostimulator

NuviQue CaHA Combo is an innovative next-generation Calcium Hydroxyapatite (CaHA) biostimulator that replaces traditional saline reconstitution with two active functional diluents—Recombinant Human Collagen (RH-Collagen) and Polynucleotide (PN). This unique triple-action system is designed to provide immediate structural support while promoting collagen stimulation and cellular regeneration in a single treatment. It is the first CaHA system to utilize RH-Collagen and PN as active diluents instead of normal saline.

Triple Combo Action

Unlike conventional CaHA products that are diluted with saline, NuviQue CA Combo combines three regenerative technologies that work together to deliver both immediate and long-term skin rejuvenation.

Calcium Hydroxyapatite (CaHA) 210MG

CaHA microspheres provide an immediate volumizing scaffold while stimulating the body’s natural collagen production. The biodegradable particles gradually break down over time, leaving newly formed collagen to maintain structural support and skin firmness.

Recombinant Human Collagen (RH-Collagen)

RH-Collagen integrates directly into the skin immediately after treatment, providing instant extracellular matrix support. It also bridges the initial collagen induction period of CaHA, helping maintain visible improvements while enhancing fibroblast activity and collagen synthesis. The leaflet states that RH-Collagen is structurally identical to human collagen and contains no animal-derived components.

Polynucleotide (PN)

PN activates regenerative signaling pathways that support skin repair, encourage growth factor release, improve cellular resilience, and help reduce post-procedure inflammation. This creates an optimal environment for collagen remodeling and recovery.

Key Benefits

• Triple-action regenerative technology combining CaHA + RH-Collagen + PN
• Immediate volume enhancement with long-term collagen stimulation
• Supports skin firmness, elasticity, and structural integrity
• Promotes cellular regeneration and tissue remodeling
• Helps minimize post-treatment inflammation and supports faster recovery
• Active diluents replace conventional saline for enhanced biological activity
• Designed to deliver continuous improvement without the typical gap between initial treatment and collagen formation

How It Works

NuviQue CA Combo utilizes three complementary mechanisms:

1. Immediate Structural Support
   • CaHA provides an instant scaffold for volume restoration.
   • RH-Collagen immediately reinforces the extracellular matrix.
2. Collagen Remodeling
   • CaHA stimulates fibroblasts to produce new collagen over the following months.
   • RH-Collagen enhances the skin environment to maximize collagen production.
3. Cellular Regeneration
   • PN activates regenerative pathways, supports tissue repair, and helps create a favorable healing environment while reducing inflammatory responses.

Product Advantages

Compared with conventional CaHA biostimulators, NuviQue CA Combo offers:

• Active functional diluents instead of saline
• Immediate collagen support through RH-Collagen
• PN-assisted regenerative signaling
• Single reconstitution protocol
• Immediate and sustained volumizing effect
• Long-lasting collagen stimulation with an expected duration of 12–18 months, according to the product comparison provided in the leaflet.

Recommended Preparation

According to the manufacturer’s protocol, sequentially inject the RH-Collagen diluent followed by the PN diluent into the CaHA vial, mix thoroughly, shake it for 15 minutes and allow the mixture to hydrate for 15  minutes before use. Injection recommendations shown in the leaflet include a 27G needle, deep dermis to subcutaneous injection depth, slow and consistent injection, gentle massage for 1–2 minutes after treatment, and a recommended retreatment interval of 4–6 weeks.